欢迎关注414lab
 
Dual Function of Magnesium in Bone Biomineralization  
发表状态：
Adv. Healthcare Mater. 2019, 1901030
研究团队：
inglun Zhang, Lin Tang, Haoning Qi, Qin Zhao, Yan Liu,* and Yufeng Zhang*
研究内容：
镁作为骨的主要成分，被广泛应用于促进骨的生长和再生。然而，mg2+可以化学
抑制非晶态磷酸钙结晶为羟基磷灰石。mg2+促进骨生物矿化的机制尚不清楚。本、
文从发育的角度论证了mg2+在骨生物矿化中的双重作用。在胚胎发育过程中，
mg2+浓度在胚胎13.5天到15.5之间的早期富集，而在胚胎15.5以后的晚期逐渐下
降到稳定状态。适当浓度的mg2+可以促进骨髓间充质干细胞的矿化，而过量的
mg2+则会损害其成骨能力。mg2+加入越早，对矿化的抑制作用越强。尤其是，
在完全矿化的胶原中，mg2+的含量比在低矿化的胶原中少。此外，高浓度的mg2+
改变了HA结构和抑制胶原钙化。在功能上，高镁饮食抑制小鼠后代的骨生物矿化。
总之，结果表明，随着时间的推移适当调节mg2+浓度对于正常的生物矿化至关重
要。这项研究对未来与mg2+含量相关的骨替代物和植入物的设计具有重要意义。
Abstract：
Magnesium (Mg2+), as a main component of bone, is widely applied to promote bone growth and regeneration. However, Mg2+ can chemically inhibit the crystallization of amorphous calcium phosphate into hydroxyapatite (HA). The underlying mechanisms by which Mg2+ improves bone iomineralization
remain elusive. Here, it is demonstrated that Mg2+ plays dual roles in bone biomineralization from a developmental perspective. During embryonic development, the Mg2+ concentration is enriched in the early stage from embryonic day 13.5 (E13.5) to E15.5, but gradually decreases to a stable state in the late phase, after E15.5. Appropriate concentrations of Mg2+ can promote the mineralization of bone marrow mesenchymal stem cells, while excessive
Mg2+ impairs their osteogenesis. The earlier the Mg2+ is added, the stronger the observed inhibition of mineralization. In particular, less Mg2+ is present in fully mineralized collagen than in poorly mineralized collagen. Furthermore,
a high concentration of Mg2+ changes the crystalline morphology of HA and inhibits collagen calcifcation. Functionally, a high-Mg2+ diet inhibits bone biomineralization in mouse offspring. Taken together, the results suggest that
appropriate regulation of Mg2+ concentration over time is vital for normal biomineralization. This study is signifcant for the future design of bone substitutes and implants associated with Mg2+ conten